International Journal of Chemical and Biological Sciences

International Journal of Chemical and Biological Sciences

Vol. 3, Issue 1, Part A (2021)

Synthesis, characterization, anti-microbial and thermal investigation study of Schiff base derived from 1,7,7-Trimethylbicyclo [2.2.1] heptan-2-one with 4-Hydroxyphenylalanine and its metal complexes

Author(s):

M Ali Hassan, N P Pranamya, G Indira Devi, Susannah Seth

Abstract:
Synthesis of bidentate Schiff base ligand by the condensation of 1,7,7-Trimethylbicyclo [2.2.1] heptan-2-one with 4-Hydroxyphenylalanineand its complexes of Co (III), Cu (II) and Cr (III). Synthesised ligand and its complexes were characterised by FT-IR, UV- Visible spectroscopy, Gouy method, molar conductance study and thermal analysis. Spectral data shows that distorted octahedral geometry of Cobalt (III), square planar geometry of Copper (II), and octahedral geometry of Chromium (III) complexes. The thermal stability of complex is explained on the reverse order of Irving William series. All the complexes are coloured, stable in air, non-electrolytic nature and soluble in DMSO solvent. The antimicrobial activity was studied using two bacteria such as Klebsiella pneumoniae and Bacillus subtilis and two fungi such as Aspergillus Niger and Candida albicans by agar well-diffusion method. The result shows that metal complexes have higher biological activity than the ligand and the Cu (II) complex show 79.31% antibacterial activity on Bacillus subtilis.

Pages: 19-25  |  454 Views  170 Downloads

How to cite this article:
M Ali Hassan, N P Pranamya, G Indira Devi, Susannah Seth. Synthesis, characterization, anti-microbial and thermal investigation study of Schiff base derived from 1,7,7-Trimethylbicyclo [2.2.1] heptan-2-one with 4-Hydroxyphenylalanine and its metal complexes. Int. J. Chem. Biol. Sci. 2021;3(1):19-25.