Vol. 7, Issue 1, Part A (2025)

N′-(5-Chloro-2-Hydroxybenzylidene)adamantane-1-carbohydrazide was synthesised and its structure was verified by elemental analysis, infrared spectroscopy, 1H nuclear magnetic resonance (NMR) and mass spectroscopy data; and in vitro cytotoxicity activities were investigated against selected cancer cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The newly synthesized compound demonstrated dose dependent activity after 48h exposure. Molecular docking studies were performed and good binding interactions (H-bonding, Van der Waal’s interaction, etc.) were observed between the drug candidate and target receptors (binding energy = −6.6 to −8.1 kcal/mol).